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. 2022 Feb 19;23(4):2307. doi: 10.3390/ijms23042307

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Network analyses revealed tear proteins with the highest level of interactions and four canonical pathways enriched in tear proteins. All 329 proteins detected in at least 50% of the samples were analyzed using Ingenuity Pathway Analysis software. (A) Proteins that showed the highest level of protein–protein interactions are depicted by cellular location. A total of four canonical pathways were highly enriched in tear proteins, including acute phase response signaling (B), glucocorticoid receptor signaling (C), LXR/RXR signaling (D), and phagosome formation (E).