Table 3.
Top 50 proteins identified in tear samples using in-strip protein digestion and HCD fragmentation.
| S. No. | UniProt ID |
Gene Symbol | Description | Mean PSM |
|---|---|---|---|---|
| 1 | P02788 | LTF | Lactotransferrin | 2802.91 |
| 2 | P31025 | LCN1 | Lipocalin-1 | 1300.64 |
| 3 | P02768 | ALB | Albumin | 874.18 |
| 4 | P12273 | PIP | Prolactin-inducible protein | 572.46 |
| 5 | P01876 | IGHA1 | Immunoglobulin heavy constant alpha 1 | 386.19 |
| 6 | P61626 | LYZ | Lysozyme C | 380.45 |
| 7 | P01833 | PIGR | Polymeric immunoglobulin receptor | 275.36 |
| 8 | Q9GZZ8 | LACRT | Extracellular glycoprotein lacritin | 263.91 |
| 9 | P01834 | IGKC | Immunoglobulin kappa constant | 230.09 |
| 10 | P0DOX2 | IGA2 | Immunoglobulin alpha-2 heavy chain | 212.87 |
| 11 | P25311 | AZGP1 | Zinc-alpha-2-glycoprotein | 203.00 |
| 12 | P0DOX7 | IGK | Immunoglobulin kappa light chain | 189.36 |
| 13 | P01036 | CST4 | Cystatin-S | 185.90 |
| 14 | O75556 | SCGB2A1 | Mammaglobin-B | 137.72 |
| 15 | Q16378 | PRR4 | Proline-rich protein 4 | 130.54 |
| 16 | P01037 | CST1 | Cystatin-SN | 115.40 |
| 17 | P19013 | KRT4 | Keratin, type II cytoskeletal 4 | 100.11 |
| 18 | Q99935 | OPRPN | Opiorphin prepropeptide | 97.72 |
| 19 | P60709 | ACTB | Actin, cytoplasmic 1 | 97.63 |
| 20 | P06733 | ENO1 | Alpha-enolase | 96.63 |
| 21 | P04083 | ANXA1 | Annexin A1 | 95.45 |
| 22 | Q9UGM3 | DMBT1 | Deleted in malignant brain tumors 1 protein | 86.00 |
| 23 | P01024 | C3 | Complement C3 | 80.54 |
| 24 | P02787 | TF | Serotransferrin | 78.72 |
| 25 | B9A064 | IGLL5 | Immunoglobulin lambda-like polypeptide 5 | 76.11 |
| 26 | Q8N3C0 | ASCC3 | Activating signal cointegrator 1 complex subunit 3 | 73.45 |
| 27 | P0DOX5 | IGG1 | Immunoglobulin gamma-1 heavy chain | 73.00 |
| 28 | P0DOY2 | IGLC2 | Immunoglobulin lambda constant 2 | 70.18 |
| 29 | P13646 | KRT13 | Keratin, type I cytoskeletal 13 | 70.11 |
| 30 | P08727 | KRT19 | Keratin, type I cytoskeletal 19 | 66.00 |
| 31 | P13647 | KRT5 | Keratin, type II cytoskeletal 5 | 56.00 |
| 32 | P09211 | GSTP1 | Glutathione S-transferase P | 51.18 |
| 33 | P68032 | ACTC1 | Actin, alpha cardiac muscle 1 | 48.10 |
| 34 | P09228 | CST2 | Cystatin-SA | 47.71 |
| 35 | P01860 | IGHG3 | Immunoglobulin heavy constant gamma 3 | 47.14 |
| 36 | P14618 | PKM | Pyruvate kinase PKM | 46.54 |
| 37 | P01591 | JCHAIN | Immunoglobulin J chain | 46.00 |
| 38 | P98160 | HSPG2 | Heparan sulfate proteoglycan core protein | 45.72 |
| 39 | P07355 | ANXA2 | Annexin A2 | 44.81 |
| 40 | P0DOX6 | IGM | Immunoglobulin mu heavy chain | 44.28 |
| 41 | P21980 | TGM2 | Protein-glutamine gamma-glutamyltransferase 2 | 43.00 |
| 42 | P01871 | IGHM | Immunoglobulin heavy constant mu | 41.90 |
| 43 | P30740 | SERPINB1 | Leukocyte elastase inhibitor | 40.54 |
| 44 | P98088 | MUC5AC | Mucin-5AC | 40.33 |
| 45 | P02538 | KRT6A | Keratin, type II cytoskeletal 6A | 40.33 |
| 46 | P00450 | CP | Ceruloplasmin | 40.18 |
| 47 | P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 | 40.18 |
| 48 | P01861 | IGHG4 | Immunoglobulin heavy constant gamma 4 | 40.00 |
| 49 | P01859 | IGHG2 | Immunoglobulin heavy constant gamma 2 | 37.90 |
| 50 | P08729 | KRT7 | Keratin, type II cytoskeletal 7 | 37.14 |