Table 4.
Major protein families identified in human tear samples.
| Families | Group | Count | Proteins | |||||
|---|---|---|---|---|---|---|---|---|
| Immunoglobulin | High | 17 | IGHV4-59 | IGHV5-51 | JCHAIN | IGHA1 | IGHM | IGKC |
| IGKV1D-33 | IGHG2 | IGLV3-9 | IGKV1-8 | IGLC2 | IGK | |||
| IGKV2D-29 | IGKV3-15 | IGHV3-7 | IGKV4-1 | IGLL5 | ||||
| Medium | 8 | IGA2 | IGKV3-20 | IGHV6-1 | IGG1 | IGHG3 | IGHG4 | |
| IGM | IGLV1-47 | |||||||
| Low | 7 | IGKV3D-11 | IGKV3-11 | IGHV3-15 | IGHV3-9 | IGHA2 | IGHG1 | |
| IGKV3D-20 | ||||||||
| Rare | 29 | IGHV1-69D | IGKV1D-8 | IGHV3-72 | IGHV3-74 | IGHV3-49 | IGHV3-33 | |
| IGKV6D-21 | IGLC1 | IGLV1-40 | IGLV1-44 | IGLV6-57 | IGSF22 | |||
| IGHV3-64D | IGHV1-18 | IGHV2-26 | IGHV3-64 | IGD | IGHV4-28 | |||
| IGHV5-10-1 | IGKV5-2 | IGKV3D-15 | IGKV1-16 | IGKV1-17 | IGKV1-6 | |||
| IGKV1D-13 | IGLV3-19 | IGLL1 | IGSF10 | |||||
| Keratin | High | 7 | KRT10 | KRT9 | KRT1 | KRT2 | KRT13 | KRT19 |
| KRT4 | ||||||||
| Medium | 5 | KRT14 | KRT5 | KRT7 | KRT6A | KRT8 | ||
| Low | 2 | KRT18 | KRT3 | |||||
| Rare | 12 | KRT15 | KRT82 | KRT85 | KRT78 | KRT31 | KRT34 | |
| KRTAP5-1 | KRT17 | KRT23 | KRT83 | KRT86 | KRT36 | |||
| Complement | High | 2 | C3 | CFB | ||||
| Medium | 2 | C4A | CD55 | |||||
| Low | 3 | C1QTNF4 | C1QB | CFH | ||||
| Rare | 10 | CFHR1 | C1QTNF2 | C9 | C1RL | C1S | C4B | |
| C7 | CFHR5 | CFI | CR1 | |||||
| Myosin | High | 4 | MYL6 | MYH14 | MYL12A | MYH8 | ||
| Medium | 1 | MYH9 | ||||||
| Low | 3 | MYO3A | MYH13 | MYH10 | ||||
| Rare | 7 | MYH15 | MYL1 | MYLK4 | MYLK | MYH2 | MYH7 | |
| MYH7B | ||||||||
| Apolipoprotein | High | 2 | APOA1 | APOA2 | ||||
| Medium | 0 | |||||||
| Low | 2 | APOD | APOB | |||||
| Rare | 7 | APOA4 | APOC3 | APOL1 | APOC2 | APOE | APOF | |
| LPA | ||||||||
| Heat shock | High | 4 | HSPA1A | HSPB1 | HSP90AA1 | HSPA8 | ||
| Medium | 1 | HSPA4 | ||||||
| Low | 1 | HSP90AB1 | ||||||
| Rare | 4 | HSP90AA2P | HSPA13 | HSPA1L | TRAP1 | |||
| Protein s100 | High | 4 | S100A11 | S100A4 | S100A8 | S100A9 | ||
| Medium | 0 | |||||||
| Low | 0 | |||||||
| Rare | 5 | S100A10 | S100A14 | S100A7L2 | S100A2 | S100A7 | ||
| Mucin | High | 1 | MUC5AC | |||||
| Medium | 0 | |||||||
| Low | 1 | MUC16 | ||||||
| Rare | 6 | MUC12 | MUC17 | MUC19 | MUC2 | MUC5B | MUC6 | |
| Annexin | High | 5 | ANXA1 | ANXA2 | ANXA5 | ANXA3 | ANXA4 | |
| Medium | 1 | ANXA11 | ||||||
| Low | 0 | |||||||
| Rare | 2 | ANXA10 | ANXA8L1 | |||||
| 14-3-3 | High | 4 | YWHAB | YWHAZ | YWHAE | SFN | ||
| Medium | 1 | YWHAG | ||||||
| Low | 1 | YWHAQ | ||||||
| Rare | 1 | YWHAH | ||||||
| Cystatin | High | 4 | CSTB | CST3 | CST4 | CST1 | ||
| Medium | 1 | CST2 | ||||||
| Low | 1 | CST5 | ||||||
| Rare | 0 | |||||||
| Peroxiredoxin | High | 4 | PRDX1 | PRDX5 | PRDX6 | PRDX2 | ||
| Medium | 0 | |||||||
| Low | 0 | |||||||
| Rare | 1 | PRDX4 | ||||||