Table 5.

Gene Ontology (GO) enrichment analysis of selected tear proteins.

GO ID	GO Term	# of Proteins	p-Value
Biological Processes
GO:0052548	Regulation of endopeptidase activity	42	1.43 × 10−22
GO:0006508	Proteolysis	79	3.50 × 10−20
GO:0006950	Response to stress	122	6.75 × 10−19
GO:0051336	Regulation of hydrolase activity	58	6.83 × 10−19
GO:0009605	Response to external stimulus	90	8.18 × 10−14
GO:0006952	Defense response	66	1.67 × 10−13
GO:0007010	Cytoskeleton organization	59	1.96 × 10−13
GO:0042592	Homeostatic process	65	4.36 × 10−12
GO:0010941	Regulation of cell death	61	8.42 × 10−12
GO:0098542	Defense response to other organism	44	1.09 × 10−09
GO:0009617	Response to bacterium	35	1.21 × 10−09
GO:0006915	Apoptotic process	62	1.26 × 10−09
GO:0006954	Inflammatory response	36	2.09 × 10−09
GO:0051050	Positive regulation of transport	38	4.16 × 10−09
GO:0022610	Biological adhesion	51	1.20 × 10−08
GO:0006793	Phosphorus metabolic process	76	1.41 × 10−08
Cellular Components
GO:0070062	Extracellular exosome	224	1.41 × 10−152
GO:1903561	Extracellular vesicle	224	1.74 × 10−148
GO:0005576	Extracellular region	244	1.35 × 10−104
GO:0072562	Blood microparticle	36	4.77 × 10−34
GO:0101002	Ficolin-1-rich granule	34	1.36 × 10−27
GO:0070161	Anchoring junction	55	3.09 × 10−21
GO:0005764	Lysosome	42	1.89 × 10−14
GO:0005773	Vacuole	44	6.14 × 10−14
GO:0030054	Cell junction	70	1.84 × 10−11
Molecular Functions
GO:0061135	Endopeptidase regulator activity	31	2.56 × 10−23
GO:0061134	Peptidase regulator activity	33	3.18 × 10−23
GO:0050839	Cell adhesion molecule binding	44	1.80 × 10−20
GO:0045296	Cadherin binding	35	4.47 × 10−20
GO:0030234	Enzyme regulator activity	63	1.35 × 10−18
GO:0008289	Lipid binding	36	1.77 × 10−09