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. 2022 Feb 16;12(2):225. doi: 10.3390/membranes12020225

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Hypoxia regulates miRNAs in BMSC-EVs. (A) The number of differentially expressed miRNAs. There were 29 differentially expressed miRNAs with a p-value < 0.05. (B) A heatmap of the 29 differentially expressed miRNAs. (C) Volcano plot displaying the 12 significant differentially expressed miRNAs based on the criteria of p < 0.05 and FC > 2 or <0.5. (D) Target gene prediction of 4 potential differentially expressed miRNAs. (913 possible target genes of these 4 miRNAs were predicted by using mirdb and TargetScan).