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Protective efficacy upon influenza viruses challenges infection. VLP immunized mice were challenge infected with lethal doses of H5N1, H3N2, or H1N1 influenza viruses 4 weeks after boost immunization. Mice were monitored daily to record body weight changes after H5N1 (A,C), H3N2 (E,G), and H1N1 (I) infections, and their survival rates post-infection with H5N1 (B,D), H3N2 (F,H) and H1N1 influenza virus (J).
