Table 1.
Major Criteria | Minor Criteria |
---|---|
Rapidly progressing course of disease (P) | Prompt alleviation of symptoms by immunosuppressants (P *) |
Reddish-violaceous wound border (P) | Characteristically irregular shape of the ulcer (P) |
Exclusion of relevant differential diagnoses (P) | Extreme pain (P) |
Neutrophilic infiltrate found in the ulcer edge (D) | Lesion at site of trauma (P) |
Exclusion of infection (D) | |
Pathergy (D) | |
History of inflammatory bowel disease or inflammatory arthitis (D) | |
History of papule, pustule, or vesicle ulcerating within 4 days of appearing (D) | |
Peripheral erythema, undermining border, and tenderness at ulceration site; (D) | |
multiple ulcerations, at least 1 on an anterior lower leg (D) | |
Cribriform or “wrinkled paper” scar(s) at healed ulcer sites (D) | |
Decreased ulcer size within 1 month of initiating immunosuppressive medication(s) (D) |
* The Paracelsus score contains three additional criteria: suppurative inflammation in histopathology, undermined wound border, systemic disease associated.