Table 2.
Genetic variants associated with an elevated risk of developing HELLP syndrome.
| Gene Variant | HELLP Compared to | Outcome | References |
|---|---|---|---|
| Glucocorticoid receptor gene (GCCR) | Healthy pregnant | Abnormal immune and glucocorticoid | Abildgaard et al. [6] |
| Bell SNP polymorphisms | Severe PE | sensitivity | |
| Toll-like receptor 4 gene (TLR4) | Healthy pregnant | Inflammation | Van Rijn et al. [68] |
| D299G | PE | Ineffective immunity | |
| T3991 | |||
| Polymorphisms | |||
| VEGF gene (VEGFA) | Healthy pregnant | Angiogenesis, vasculogenesis | Nagy et al. [69] |
| C−460T | Healthy pregnant | arterial muscular relaxation | |
| G+405C | |||
| Polymorphisms | |||
| Fas (TNFRSF6) gene, homozygous | Healthy pregnant | Immune regulation, apoptosis | Sziller et al. [70] |
| Polymorphism in A−670G | Liver disease | ||
| FV Leiden | Healthy pregnant | Thrombophilia | Muetze et al. [71] |