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. 2022 Feb 11;10(2):416. doi: 10.3390/microorganisms10020416

Table 2.

MLST profile, hypermucoviscosity phenotype, resistance and virulence determinants, porin mutation, and plasmid replicons of carbapenem-resistant K. pneumoniae strains.

ID FMUL MLST Hypermucoviscosity
Phenotype
Resistance Profile Virulence Profile K Locus O Locus
OmpK Mutations Plasmid Replicons
Carbapenemases β-Lactamases Other Resistance Genes Yersiniabactin Colibactin
5 231 no KPC-3 OXA-9 aac(3)-IId;aadA;aadA16;strA;strB; catII.2; arr-3; sul1;sul2; tet(D); dfrA1;dfrA14*;dfrA27; GyrA-83I;ParC-80I ybt 9; ICEKp3 - KL51 O1v2 - ColKP3; IncFIA(HI1); IncFIB(K)(pCAV1099-114); IncR; IncX3
17 348 no KPC-3; OXA-181 OXA-9; TEM-1D; SHV-11 aac(6′)-Ib’;strA;strB; qnrB1;qnrS1;
sul2; dfrA14
ybt unknown - KL62 O1v1 OmpK36-0% ColKP3; IncFIA(HI1); IncFIB(K)(pCAV1099-114); IncFII(K); IncR; IncX3
20 147 no OXA-181 TEM-1D; CTX-M-15; SHV-1 aac(6′)-Ib-cr;aadA16;strA;strB; qnrS1; arr-3; sul1;sul2; dfrA27; GyrA-83I;ParC-80I ybt 16; ICEKp12 - KL64 O2v1 - FIA(pBK30683); FII(pBK30683); IncFIB(K); IncFII(K)
22 13 no KPC-3 OXA-9; TEM-1D; SHV-1 aac(6′)-Ib’;aadA;strA;strB; sul2; dfrA14 ybt 17; ICEKp10 clb 3 KL3 O1v2 - ColKP3; IncFIA(HI1); IncFIB(K)(pCAV1099-114); IncR; IncX3
24 17 no OXA-181 OXA-1; CTX-M-15;
SHV-11
aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strB; qnrB4;qnrS1; catII.2; arr-3; sul1;sul2; dfrA27 - - KL25 O5 - ColRNAI; FIA(pBK30683); FII(pBK30683)
26 147 no OXA-181 TEM-1D; CTX-M-15 aac(6′)-Ib-cr;aadA16;strA;strB; qnrS1; arr-3; sul1;sul2; dfrA27; GyrA-83I;ParC-80I ybt 16; ICEKp12 - KL64 O2v1 - ColRNAI; FIA(pBK30683); FII(pBK30683)
27 17 no OXA-181 TEM-1D; CTX-M-15; SHV-1 aac(6′)-Ib-cr;aadA16;strA;strB; qnrS1; arr-3; sul1;sul2; tet(D); dfrA14;dfrA27 ybt 16; ICEKp12 - KL25 O5 - ColRNAI; FIA(pBK30683); FII(pBK30683)
43 17 no OXA-181 SHV-11 aac(6′)-Ib-cr;aadA16;strA;strB; catII.2; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL25 O5 - ColKP3, IncFIA(HI1), IncFIB(K)(pCAV1099-114), IncM1, IncR, IncX3
45 17 no OXA-181 TEM-1D;
CTX-M-15; SHV-11
aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strB; qnrS1; mphA; catII.2; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL25 O5 - IncFIB(K); IncFIB(pKPHS1); IncFII(K); IncX3
48 17 no OXA-181 SHV-11 aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strB; qnrS1; catII.2; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL25 O5 - ColRNAI; FIA(pBK30683); FII(pBK30683)
60 34 no KPC-3 TEM-1D; SHV-26 strA;strB; sul2; dfrA14 - - KL153 O1v2 - IncFIB(K); IncFIB(pQil); IncFII(K); IncX3
71 17 no OXA-181 OXA-1; TEM-1D; CTX-M-15; SHV-11 aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strB; qnrS1; mphA; catII.2; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL25 O5 - IncC; IncFIB(K)(pCAV1099-114); IncFII(K)
81 37 no KPC-3 OXA-9; TEM-1D; SHV-11 aac(6′)-Ib’;aadA;strA;strB; sul2; dfrA14 ybt 10; ICEKp4 - KL14 O3b - IncFIB(K); IncFII(K)
92 13 yes KPC-3 OXA-9; TEM-1D; SHV-1 aac(6′)-Ib’;aadA;strA;strB; sul2; dfrA14; GyrA-87N ybt 17; ICEKp10 clb 3 KL3 O1v2 OmpK35-70% Col440I; Col440II; FIA(pBK30683); FII(pBK30683); IncFIA(HI1); IncFIB(K); IncR
99 13 yes KPC-3 OXA-9; TEM-1D; SHV-1 aac(6′)-Ib’;aadA;strA;strB; sul2; dfrA14; GyrA-87N ybt 17; ICEKp10 clb 3 KL3 O1v2 OmpK35-70% ColRNAI; FII(pBK30683); IncFIB(K); IncFII(K)
101 323 no KPC-3 OXA-1; OXA-9;
TEM-1D; SHV-1
aac(3)-IIa;aadA;strA;strB; qnrB1; sul2; tet(A); dfrA14; GyrA-83F - - KL21 O3b - FIA(pBK30683), FII(pBK30683), IncFIB(K), IncFII(K)
102 392 no - OXA-1; TEM-1D; CTX-M-15; SHV-11 aac(3)-IIa;aac(6′)-Ib-cr;strA;strB; qnrB1; sul2; tet(A); dfrA14; GyrA-83I;ParC-80I - - KL27 O4 OmpK35-58%;
OmpK36-0%
IncFIB(K), IncFII(K)
116 147 no OXA-181 TEM-1D; CTX-M-15; SHV-1 aac(6′)-Ib-cr;aadA16;strA;strB; qnrS1; arr-3; sul1;sul2; dfrA27; GyrA-83I;ParC-80I ybt 16; ICEKp12 - KL64 O2v1 - IncFIA(HI1); IncFIB(K); IncR
122 13 yes KPC-3 OXA-9; TEM-1D; SHV-1 aac(6′)-Ib’;aadA;strA;strB; sul2; dfrA14; GyrA-87N ybt 17; ICEKp10 clb 3 KL3 O1v2 OmpK35-70% IncFIA(HI1); IncFIB(K); IncR
127 29 yes OXA-181 - qnrS1; tet(D) ybt 10; ICEKp4 - KL54 O1v2 - IncFIA(HI1); IncFIB(K); IncR
132 37 no KPC-3 OXA-9; TEM-1D; SHV-11 aac(6′)-Ib’;aadA;strA;strB; sul2; dfrA14 ybt 10; ICEKp4 - KL14 O3b - ColRNAI; FIA(pBK30683); FII(pBK30683); IncFIB(K); IncFII(K); IncR
181 13 no KPC-3 OXA-9; TEM-1D; CTX-M-15; SHV-1 aac(6′)-Ib’; aadA; aadA5; strA;strB; qnrS1; mphA; sul1;sul2; tet(D); dfrA14;dfrA17 ybt 9; ICEKp3 - KL3 O1v2 - IncFIB(K); IncFII(K)
184 348 no KPC-3 OXA-9; TEM-1D; SHV-11 strA;strB; qnrB1; sul2; dfrA14 ybt unknown - unknown O1v1 - Col(pHAD28); FIA(pBK30683); FII(pBK30683); IncFIB(K); IncFII(K); IncFII(K); IncX3
224 39 no NDM-1 OXA-1; OXA-10; TEM-1D; CTX-M-15; SHV-11 aac(3)-IIa;aac(6′)-Ib-cr;aadA;aph3-Ia;armA;strA;strB; qnrB1;qnrS1; mphE;msrE; catII.2;cmlA5; arr-2; sul2; tet(A); dfrA14;dfrA7 ybt 15; ICEKp11 - KL62 O1v2 - IncFIA(HI1); IncFIB(K); IncL; IncR
233 307 yes - OXA-1; TEM-1D; CTX-M-15; SHV-28 aac(3)-IIa;aac(6′)-Ib-cr;strA;strB; qnrB1; sul2; tet(A); dfrA14; GyrA-83I;ParC-80I ybt 9; ICEKp3 - KL102 O2v2 OmpK36-75% FIA(pBK30683); FII(pBK30683); IncM1
245 307 yes KPC-3 OXA-1; TEM-1D; CTX-M-15; SHV-28 aac(3)-IIa;aac(6′)-Ib-cr;strA;strB; qnrB1; sul2; tet(A); dfrA14*; GyrA-83I;ParC-80I ybt 9; ICEKp3 - KL102 O2v2 OmpK36-75% Col(pHAD28); IncFIB(K); IncFIB(pKPHS1); IncFIB(pNDM-Mar); IncFII(Yp); IncL
247 307 yes - OXA-1; TEM-1D; CTX-M-15; SHV-28 aac(3)-IIa;aac(6′)-Ib-cr;strA;strB; qnrB1; sul2; tet(A); dfrA14; GyrA-83I;ParC-80I ybt 9; ICEKp3 - KL102 O2v2 OmpK36-75% Col(pHAD28); IncFIB(K); IncFIB(pKPHS1); IncFIB(pNDM-Mar); IncFII(Yp); IncL
248 13 no KPC-3 TEM-1D; SHV-1 strA;strB; catA4;floR; sul2; tet(D);tet(J); dfrA1;dfrA14 ybt 17; ICEKp10 clb 3 KL19 O1v2 - IncFIB(K); IncFIB(pKPHS1); IncFIB(pNDM-Mar); IncFII(Yp); IncL
257 29 no GES-5 BEL-1; SHV-187 aac(6′)-Ib4 ybt 17; ICEKp10 clb 3 KL30 O1v2 - IncFIA(HI1); IncFIB(K); IncR; ColRNAI
274 307 yes - OXA-1; TEM-1D; CTX-M-15; SHV-28 aac(3)-IIa^;aac(6′)-Ib-cr;strA^;strB; qnrB1^; sul2; tet(A); dfrA14; GyrA-83I;ParC-80I ybt 9; ICEKp3 - KL102 O2v2 OmpK36-75% FII(pBK30683); IncFIB(K); IncFII(K); IncR
296 147 no OXA-181 TEM-1D; CTX-M-15 aac(6′)-Ib-cr;aadA16;strA;strB; qnrS1; arr-3; sul1;sul2; dfrA27; GyrA-83I;ParC-80I ybt 16; ICEKp12 - KL64 O2v1 - IncFIB(K), IncFIB(pKPHS1), IncFII(K), IncX3
345 5840 no KPC-3 OXA-9; TEM-1D; SHV-1 aac(6′)-Ib’;aadA;strA;strB; sul2; dfrA14 ybt 10; ICEKp4 - KL5 O3b - ColKP3; ColRNAI; FIA(pBK30683); FII(pBK30683); IncFIB(K); IncFII(K); IncR; IncX3
363 3031 yes - SHV-1 - ybt 10; ICEKp4 - KL24 O2v1 - IncFIB(K)
443 17 no OXA-181 OXA-1; SHV-11 aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strA;strB; qnrS1; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL25 O5 - ColKP3; IncFIA(HI1); IncFIB(K) (pCAV1099-114); IncFII(K); IncR; IncX3
447 231 no - OXA-1; TEM-1D; CTX-M-15; SHV-1 aac(3)-IIa;aac(6′)-Ib-cr;aadA2;aph3-Ia;strA;strB; qnrB1; mphA; sul1;sul2; dfrA12;dfrA14; GyrA-83I;ParC-80I ybt 10; ICEKp4 - KL51 O1v2 - ColKP3; ColRNAI; FIA(pBK30683); FII(pBK30683); IncFIB(K); IncFII(K); IncR; IncX3
449 13 no KPC-3; OXA-181 TEM-1D; SHV-1 strA;strB; qnrS1; sul2; tet(D); dfrA14 ybt 17; ICEKp10 clb 3 KL19 O1v2 - IncFIB(K); IncFIB(pKPHS1); IncFII(K); IncR; IncX3
451 17 no OXA-181 OXA-1; TEM-1D; CTX-M-15; SHV-11 aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strA;strB; qnrS1; mphA; arr-3; sul1; dfrA27 ybt 16; ICEKp12 - KL25 O5 - ColKP3; IncFIA(HI1); IncFIB(K)(pCAV1099-114); IncR; IncX3
460 13 yes KPC-3; OXA-181 TEM-1D; SHV-1 strA;strB; qnrS1; sul2; tet(D); dfrA14 ybt 17; ICEKp10 clb 3 KL19 O1v2 - IncFIA(HI1); IncFIB(K); IncR
462 17 no OXA-181 OXA-1; TEM-1D; CTX-M-15 aac(3)-IIa;aac(6′)-Ib-cr;aadA16;aadA;strA;strB; qnrS1; mphA; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL25 O5 - ColRNAI; FIA(pBK30683); FII(pBK30683); IncFIB(K); IncFIB(pKPHS1); IncFII(K); IncR;
463 17 no OXA-181 OXA-1; TEM-1D; CTX-M-15; SHV-11 aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strB; qnrS1; mphA; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL25 O5 - IncFIB(K); IncFIB(pKPHS1); IncFII(K); IncR
465 17 no OXA-181 OXA-1; TEM-1D;CTX-M-15; SHV-11 aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strB; qnrS1; mphA; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL25 O5 - ColKP3; IncFIA(HI1); IncFIB(K)(pCAV1099-114); IncFII(K); IncR; IncX3
467 45 no KPC-3 TEM-1D; SHV-1 strA;strB; sul2; tet(D); dfrA14 ybt 10; ICEKp4 - KL62 O2v1 - IncFIB(K); IncFIB(pKPHS1); IncFII(K); IncX3
470 45 no - OXA-1; TEM-1D; CTX-M-15; SHV-1 aac(3)-IIa;aac(6′)-Ib-cr;strA;strB; qnrB1; sul2; dfrA14 ybt 10; ICEKp4 - KL62 O2v1 - ColRNAI; FIA(pBK30683); FII(pBK30683); IncFIB(K)
471 17 no OXA-181 TEM-1; CTX-M-15;
SHV-11
aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strA;strB; qnrS1; mphA; arr-3; sul1; dfrA27 ybt 16; ICEKp12 - KL25 O5 - ColRNAI; FIA(pBK30683); FII(pBK30683); IncFIB(K)
473 45 no OXA-181 OXA-1; TEM-1D;CTX-M-15; SHV-1 aac(3)-IIa;aac(6′)-Ib-cr;strA;strB; qnrB1;qnrS1; sul2; tet(D); dfrA14 ybt 10; ICEKp4 - KL62 O2v1 - ColKP3; ColRNAI; FIA(pBK30683); FII(pBK30683); IncFIB(K); IncFII(K); IncR; IncX3
476 17 no OXA-181 OXA-1; TEM-1D; CTX-M-15; SHV-11 aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strA;strB; qnrS1; mphA; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL25 O5 - IncFIB(K); IncFII(K)
498 13 yes KPC-3; OXA-181 TEM-1D; SHV-1 strA;strB; qnrS1; sul2; tet(D); dfrA14 ybt 17; ICEKp10 clb 3 KL19 O1v2 - IncFIB(K); IncFII
499 307 no - OXA-1; TEM-1D; CTX-M-15; SHV-28 aac(3)-IIa;aac(6′)-Ib-cr;strA;strB; qnrB1; sul2; tet(A); dfrA14; GyrA-83I;ParC-80I ybt 9; ICEKp3 - KL102 O2v2 OmpK35-30% ColRNAI; FIA(pBK30683); FII(pBK30683); IncFIB(K); IncFII(K); IncR
500 307 no - OXA-1; TEM-1D; CTX-M-15; SHV-28 aac(3)-IIa;aac(6′)-Ib-cr;strA;strB; qnrB1; sul2; tet(A); dfrA14; GyrA-83I;ParC-80I ybt 9; ICEKp3 - KL102 O2v2 OmpK35-30% ColKP3; IncFIA(HI1); IncFIB(K) (pCAV1099-114); IncR; IncX3
501 3031 no - CTX-M-15 aadA5; qnrS1; mphA; sul1; dfrA17 ybt 10; ICEKp4 - KL24 O2v1 OmpK36-85% Col156; ColKP3; IncFIA(HI1); IncFIB(AP001918); IncFIB(K)(pCAV1099-114); IncFII; IncR; IncX3
502 147 no OXA-181 TEM-1D; CTX-M-15 aac(6′)-Ib-cr;aadA16;strA;strB; qnrS1; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL64 O2v1 - IncFIB(K)(pCAV1099-114); IncFIB(pQil); IncFII(K)
516 13 no KPC-3 TEM-1D^ strA;strB; sul2; tet(D); dfrA14 ybt 17; ICEKp10 clb 3 - O1/O2v2 - Col440II; ColRNAI; FIA(pBK30683); FII(pBK30683); IncFIB(K)
517 13 no KPC-3 TEM-1D; SHV-1 strA;strB; sul2; tet(D); dfrA14 - - - O1/O2v2 - IncFIB(K)(pCAV1099-114); IncFIB(pQil); IncFII(K)
522 661 no - OXA-10; TEM-1D; SHV-27 aac(6′)-Ib;aadA;aadA2;strA;strB; qnrS1; mphA; sul1;sul2; tet(A); dfrA12;dfrA14 ybt 14; ICEKp5 - KL27 O2v2 - ColKP3; ColRNAI; FIA(pBK30683); FII(pBK30683); IncFIB(K); IncFII(K); IncR; IncX3
523 13 no KPC-3 TEM-1D strA^;strB; sul2; tet(D); dfrA14 ybt 17; ICEKp10 clb 3 - O1v2 - IncFIB(K); IncFII(K)
533 661 no - OXA-10; TEM-1D; SHV-27 aac(6′)-Ib’;aadA;aadA2;strA;str; qnrS1; mphA; sul1;sul2; tet(A); dfrA12;dfrA14 ybt 14; ICEKp5? - KL27 O2v2 - IncFIB(K); IncFIB(pKPHS1); IncFII(K); IncN
535 13 no KPC-3; OXA-181 TEM-1D; SHV-1 strA;strB; qnrS1; sul2; tet(D); dfrA14* ybt 17; ICEKp10 clb 3 - O1v2 - Col440I; FIA(pBK30683); FII(pBK30683); IncFII(pCoo); IncN
548 307 no - OXA-1; TEM-1;
CTX-M-15; SHV-28
aac(3)-IIa;aac(6′)-Ib-cr;strA;strB; qnrB1; sul2; tet(A); dfrA14 ybt 9; ICEKp3 - KL102 O2v2 - Col156; IncFIB(AP001918); IncFIB(pKPHS1); IncFII; IncN
584 17 no OXA-181 OXA-1; CTX-M-15;
SHV-11
aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strA;strB; qnrS1; mphA; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL25 O5 - FIA(pBK30683); FII(pBK30683)
592 17 no OXA-181 TEM-1D; CTX-M-15; SHV-11 aac(3)-IIa;aac(6′)-Ib-cr;aadA16;strB; qnrS1; mphA; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL25 O5 - Col440I; FIA(pBK30683); FII(pBK30683); IncR
595 485 no KPC-3 TEM-1D; SHV-1 aadA;strA^;strB; sul2; dfrA14 ybt 10; ICEKp4 - - OL101 - Col440II; FIA(pBK30683); FII(pBK30683); IncFIB(K)(pCAV1099-114)
596 147 no OXA-181 TEM-1D; CTX-M-15-; SHV-1 aac(6′)-Ib-cr;aadA16;strA^;strB; qnrS1; arr-3; sul1;sul2; dfrA27 ybt 16; ICEKp12 - KL64 O2v1 - IncFIB(K); IncFII(K)
648 13 no KPC-3; OXA-48 TEM-1D; SHV-1 strA^;strB; sul2; tet(D); dfrA14 ybt 17; ICEKp10 clb 3 KL19 O1v2 - ColRNAI, FIA(pBK30683), FII(pBK30683), IncFIB(K), IncL
679 307 no - SHV-28 GyrA-83I;ParC-80I ybt 9; ICEKp3 - KL102 O2v2 - -
680 231 no KPC-3 - aac(6′)-Ib; dfrA14; GyrA-83I;ParC-80I ybt 9; ICEKp3 - KL51 O1/O2v2 - Col440I, Col440II, FIA(pBK30683), FII(pBK30683), IncFIB(K), IncFII(K), IncR
681 13 no KPC-3 TEM-1D strA;strB; sul2; tet(D); dfrA14 ybt 17; ICEKp10 clb 3 KL19 O1v2 - ColRNAI, FIA(pBK30683), FII(pBK30683), IncFIB(K)
683 13 no KPC-3 TEM-1D; SHV-1 strA;strB; sul2; dfrA14; GyrA-87N ybt 17; ICEKp10 clb 3 KL3 O1v2 - ColRNAI, FIA(pBK30683), FII(pBK30683)
685 13 no KPC-3 TEM-1D; SHV-1 strA;strB; sul2; tet(D); dfrA14 ybt 17; ICEKp10 clb 3 KL19 O1v2 - ColRNAI, FIA(pBK30683), FII(pBK30683), IncFIB(K)