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. 2022 Feb 18;23(4):2274. doi: 10.3390/ijms23042274

Figure 4.

Figure 4

EB3 potentiates spine localization of CaMKII-alpha. (A) Confocal images of WT primary hippocampal dendrites and dendrites in condition of amyloid toxicity (Ab) co-transfected with Venus-CaMKII-alpha and mCherry infected with lentiviruses encoding EB3, control RNAi (shControl), or RNAi against EB3 (shEB3) at DIV 8-9 and fixed at DIV 16-17. Scale bar corresponds to 5μm. (B) The ratio of the CaMKII-alpha fluorescence intensity in spines to parent dendrite normalized to the mCherry. *: p < 0.05, **: p < 0.01, ***: p < 0.001. Student-t test. n ≥ 53 spines from 4 batches of cultures.