Table 3.
Association of demographic and clinical characteristics with positive SARS-CoV-2-specific IL-2 reactivity (A) and IFN-γ reactivity (B) at T1 and T2.
| (A) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | T1a |
T2b |
||||||||||
| Univariate association |
Multivariate association |
Univariate association |
Multivariate association |
|||||||||
| OR | 95% CI | p-value | OR | 95% CI | p-value | OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Age | 0.982 | (0.944–1.02) | 0.353 | 0.967 | (0.927–1.008) | 0.114 | ||||||
| Diabetes mellitus (yes)c | 1.25 | (0.320–4.8) | 0.748 | 0.733 | (0.192–2.806) | 0.651 | ||||||
| Dialysis modality (PD)c | 0.353 | (0.033–3.7) | 0.387 | 0 | (0–0) | 0.999 | ||||||
| Dialysis duration | 1 | (0.988–1.001) | 0.880 | 1.001 | (0.990–1.013) | 0.853 | ||||||
| Previous COVID-19 infection (recovered)c | 7.69 | (0.805–73.5) | 0.077d | 5 | (0.466–53.6) | 0.184 | ||||||
| Type of vaccine (vector vaccine)c | 0.353 | (0.33–3.7) | 0.387 | 0.429 | (0.040–4.57) | 0.483 | ||||||
| SARS-CoV-2 anti-spike antibodies (in 10,000) | 2.44 | (1.1–5.4) | 0.028d | 2.401 | (1.102–5.402) | 0.028 | 6.848 | (1.487–31.5) | 0.014d | 6.848 | (1.487–31.50) | 0.014 |
| Immunosuppressive drugs (yes)c | 0.750 | (0.111–5.074) | 0.768 | 0 | (0–0) | 0.999 | ||||||
| CRP | 1.053 | (0.983–1.128) | 0.140 | 0.957 | (0.890–1030) | 0.241 | ||||||
| IL-6 | 0.931 | (0.825–1.050) | 0.243 | 0.905 | (0.775–1057) | 0.209 | ||||||
| Ferritin | 1 | (0.999–1.002) | 0.807 | 1 | (0.998–1001) | 0.615 | ||||||
|
| ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (B) | ||||||||||||
| Variable | T1a |
T2a |
||||||||||
| Univariate association |
Multivariate association |
Univariate association |
Multivariate association |
|||||||||
| OR | 95% CI | p-value | OR | 95% CI | p-value | OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Age | 0.989 | (0.949–1.032) | 0.622 | 0.975 | (0.939–1.013) | 0.201 | ||||||
| Diabetes mellitus (yes)b | 1.190 | (0.291–4.867) | 0.808 | 0.794 | (0.219–2.880) | 0.725 | ||||||
| Dialysis modality (PD)b | 0.640 | (0.067–6.142) | 0.699 | 0.446 | (0.047–4.210) | 0.481 | ||||||
| Dialysis duration | 1.004 | (0.989–1.018) | 0.618 | 1.004 | (0.990–1.018) | 0.599 | ||||||
| Previous COVID-19 infection (recovered)b | 1.195e+10 | (0–0) | 0.999 | 5.493e+9 | (0–0) | 0.999 | ||||||
| Type of vaccine (vector vaccines)b | 0.640 | (0.067–6.142) | 0.699 | 0.577 | (0.059–5.674) | 0.637 | ||||||
| SARS-CoV-2 anti-spike antibodies (in 10,000) | 4.18 | (1.6–10.8) | 0.003c | 4.18 | (1.62–10.80) | 0.003 | 9.447 | (2.047–43.60) | 0.004c | 9.447 | (2.047–43.60) | 0.004 |
| Immunosuppressive drugs (yes)b | 0.640 | (0.067–6.14) | 0.699 | 2.667 | (0.337–21.11) | 0.353 | ||||||
| CRP | 0.997 | (0.978–1.016) | 0.730 | 0.973 | (0.931–1.016) | 0.216 | ||||||
| IL-6 | 0.952 | (0.847–1.069) | 0.402 | 0.948 | (0.864–1.040) | 0.261 | ||||||
| Ferritin | 1 | (0.999–1.001) | 0.570 | 1.001 | (1–1.003) | 0.090c | ||||||
Bolded p-values denote statistical significance at the p < 0.05 level.
aThirty-nine cases were included in the logistic regression analysis due to missing cases.
bThirty-six cases were included in the logistic regression analysis due to missing cases.
cRefers to indicator.
dRefers to variables included in the multivariate logistic regression analysis with backward elimination.
95% CI, 95% confidence interval; COVID-19, coronavirus disease 2019; CRP, C-reactive protein; IL-6, interleukin-6; OR, odds ratio; PD, peritoneal dialysis; SARS-CoV-2, severe acute respiratory syndrome coronavirus type 2; T1, timepoint 1; T2, timepoint 2.
Bolded p-values denote statistical significance at the p < 0.05 level.
aForty-eight cases were included in the logistic regression analysis due to missing cases.
bRefers to indicator.
cRefers to variables included in the multivariate logistic regression analysis with backward elimination.
95% CI, 95% confidence interval; COVID-19, coronavirus disease 2019; CRP, C-reactive protein; IL-6, interleukin-6; OR, odds ratio; PD, peritoneal dialysis; SARS-CoV-2, severe acute respiratory syndrome coronavirus type 2; T1, timepoint 1; T2, timepoint 2.