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. 2022 Jan 20;14(2):233. doi: 10.3390/pharmaceutics14020233

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Action of GNP-BLM complex. (A) The phases of the cell cycle. As a cell prepares for division it goes through three different phases: G1 is the gap between M and S phase, DNA replication occurs in S phase and G2 is when the cell prepares for mitosis (B,C) Cell proliferation as a function of concentration for GNP-BLM and GNP complexes IN MIA PaCa-2 and PC-3, respectively. Y-axis represents cell viability. (D) Polarization modulation infrared reflection absorption spectroscopy data showing the presence of BLM on GNPs. (E,F) Distribution of cell cycle phase after treatment with 1 nM concentration of GNP complex, GNP-BLM, and free BLM in MIA PaCa-2 and PC-3.