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The time-dependent RMSD (A) and RMSF (B) curves of wild-type CR3022–SARS-CoV-2 RBD system (in blue) and its two double-site mutated complexes (S103F–S33R–RBD, in red and S103Y–S33R–RBD, in green) during 100 ns MD simulation. The approximate CDR locations in the heavy and light chain (CDR1, CDR2 and CDR3) with IMGT number were respectively marked with a black frame.
