Figure 3.

M1/M2 related WGCNA and module enrichment analyses. (A) Visual representations of the gene co-expression network. Hierarchical clustering of 2185 genes and visualization of gene module partitioning. Coloured bars (below) directly correspond to module (colour) designation for gene clusters. One can visualize where in the clustering dendrogram the gene modules are defined. (B) Heatmap showing the average genetic significance of each particular module across immune infiltration levels. (C) The correlation between module membership and gene significance in the three modules. (D) Enrichment analysis. The left side is the gene (the shade of the colour represents the gene’s fold change), while the right side are the different GO terms. Connected bands indicate that a gene is in its corresponding GO terms. (E) Co-expression network diagram. Top 40 hub genes were selected and visualized. Colour shades represent the number of connections.