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. 2022 Feb 18;14(4):862. doi: 10.3390/nu14040862

Figure 12.

Figure 12

If an inability to generate sufficient ATP in the exercising muscles was the key factor ‘limiting’ exercise performance during prolonged exercise then, in this unregulated system, the sole outcome would always be the development of skeletal muscle rigor. Since skeletal muscle rigor does not happen during any form of exercise, skeletal muscle function (and metabolism) must be homeostatically regulated, specifically to prevent this catastrophic outcome.