Table 2.

Portended physiochemical parameters and structural descriptors of T3D2489, T3D2672, T3D2378, and XF7 as SARS-CoV-2 main protease (M^pro) inhibitors.

Compound Name/Code	milogP	TPSA	nON	nOHNH	Nrotb	MWt	%ABS
T3D2489	0.03	128.5	8	7	18	435.6	64.7%
T3D2672	6.7	163.7	13	4	9	842.1	52.5%
T3D2378	1.7	61.9	6	1	4	385.5	87.6%
XF7	4.3	109.9	8	2	6	492.5	71.1%