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. 2022 Feb 18;10(2):325. doi: 10.3390/vaccines10020325

Table 1.

Reported patients with aseptic meningitis after COVID-19-vaccinations.

Saito et al. Lee Reis Carneiro et al. Tagini et al. Dupon et al. Current Case
Age/sex 42 y/female 18 y/male 62 y/female late 20s/female 34 y/female 15 y/male
Vaccine BNT162b2 BNT162b2 BNT162b2 mRNA-1273 BNT162b2 BNT162b2
Onset of symptoms # 7 days 3 weeks 1 day 1–2 weeks 6–8 h 10 days
Vaccine dose 1st 2nd 1st 2nd 2nd 2nd
Preexisting
conditions
migraine - dyslipidemia,
anxiety
polycystic ovary
syndrome
- knee surgery
1 month ago
Accompanying
Symptoms
- - - oral and genital aphthous ulcers, pseudofolliculitis, intracranial hypertension joint pain in wrists,
ankles and knees,
petechiae on lower
extremities
oral aphthous ulcers, pustular skin lesion,
erythema nodosum-like lesions, joint effusion,
vitreous floaters
C-reactive protein 9.85 mg/dL 0.74 mg/dL n.r. 10.9 mg/dL 16.9 mg/dL 5.34 mg/dL
CSF pleocytosis 176/µL
(64.1% mononuclear,
34.8% granular)
115/µL
(99.1% mononuclear)
1st LP: 101/µL
2nd LP: 301/µL
(100% lymphocytes)
27/µL
(98% lymphocytes,
2% monocytes)
188/µL
(lymphocytic pattern)
242/µL
(55% mononuclear,
45% granular)
CSF protein level 35.7 mg/dL (ref. 0–45) 67.2 mg/dL (ref. 20–45) 1st LP: 154 (ref. 15–40)
2nd LP: 208 (ref. 15–40)
55.1 mg/dL (ref. 15–45) n.r. 69.4 mg/dL (ref. 15–40)
CSF/serum Ig-indices IgG normal
(IgA and IgM n.r.)
n.r. n.r. n.r. n.r. IgA and IgM elevated
IgG normal
cMRI normal subtle leptomeningeal
enhancement
normal intracranial hypertension normal subtle leptomeningeal
enhancement
Immunusuppressive
treatment
methylprednisolone no dexamethasone colchicine, prednisone, (after 1.5 months AZA) methylprednisolone no
Recovery complete complete complete incomplete, persistent intracranial hypertension, retinitis after 1.5 months complete complete

n.r. = not reported; AZA = azathioprine; # = onset of meningitis-related symptoms.