Table 1.
Saito et al. | Lee | Reis Carneiro et al. | Tagini et al. | Dupon et al. | Current Case | |
---|---|---|---|---|---|---|
Age/sex | 42 y/female | 18 y/male | 62 y/female | late 20s/female | 34 y/female | 15 y/male |
Vaccine | BNT162b2 | BNT162b2 | BNT162b2 | mRNA-1273 | BNT162b2 | BNT162b2 |
Onset of symptoms # | 7 days | 3 weeks | 1 day | 1–2 weeks | 6–8 h | 10 days |
Vaccine dose | 1st | 2nd | 1st | 2nd | 2nd | 2nd |
Preexisting conditions |
migraine | - | dyslipidemia, anxiety |
polycystic ovary syndrome |
- | knee surgery 1 month ago |
Accompanying Symptoms |
- | - | - | oral and genital aphthous ulcers, pseudofolliculitis, intracranial hypertension | joint pain in wrists, ankles and knees, petechiae on lower extremities |
oral aphthous ulcers, pustular skin lesion, erythema nodosum-like lesions, joint effusion, vitreous floaters |
C-reactive protein | 9.85 mg/dL | 0.74 mg/dL | n.r. | 10.9 mg/dL | 16.9 mg/dL | 5.34 mg/dL |
CSF pleocytosis | 176/µL (64.1% mononuclear, 34.8% granular) |
115/µL (99.1% mononuclear) |
1st LP: 101/µL 2nd LP: 301/µL (100% lymphocytes) |
27/µL (98% lymphocytes, 2% monocytes) |
188/µL (lymphocytic pattern) |
242/µL (55% mononuclear, 45% granular) |
CSF protein level | 35.7 mg/dL (ref. 0–45) | 67.2 mg/dL (ref. 20–45) | 1st LP: 154 (ref. 15–40) 2nd LP: 208 (ref. 15–40) |
55.1 mg/dL (ref. 15–45) | n.r. | 69.4 mg/dL (ref. 15–40) |
CSF/serum Ig-indices | IgG normal (IgA and IgM n.r.) |
n.r. | n.r. | n.r. | n.r. | IgA and IgM elevated IgG normal |
cMRI | normal | subtle leptomeningeal enhancement |
normal | intracranial hypertension | normal | subtle leptomeningeal enhancement |
Immunusuppressive treatment |
methylprednisolone | no | dexamethasone | colchicine, prednisone, (after 1.5 months AZA) | methylprednisolone | no |
Recovery | complete | complete | complete | incomplete, persistent intracranial hypertension, retinitis after 1.5 months | complete | complete |
n.r. = not reported; AZA = azathioprine; # = onset of meningitis-related symptoms.