Skip to main content
. 2022 Feb 15;23(4):2150. doi: 10.3390/ijms23042150

Figure 5.

Figure 5

(a) Reduction in tumor size (primary xenografts) in BALB/c mice. BALB/c mice bearing 4T1 cells as xenografts were intraperitoneally treated with 50 mg/kg Cur and Pacli daily, individually and in combination with AuNP for 3 weeks. CP combination decreased tumor size more efficiently when conjugated with AuNP. (b) The size of tumors was measured externally in the experimental mice using a Vernier caliper at different time points (days 1, 10, and 21) and it was observed that the tumors regressed with the experimental treatments. (c) Histopathological evaluation of metastasis in breast fat pad and liver of the Balb/c mice that were treated with 50 mg/kg.bw Cur, Pacli, CP, Au-C, Au-P, and Au-CP. (d) The in vivo expression of STAT3, MMP2/3/9, Cyclin D, and VEGF was downregulated in rat tissues treated with 50 mg/kg Cur and Pacli individually and 25 mg/kg in combinations of CP with and without AuNPs groups [19]. **** p-value: <0.0001, *** p-value: <0.001, ** p-value: ≤0.01.