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. 2022 Feb 3;14(2):314. doi: 10.3390/v14020314

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cell death induced by IBV infection can be rescued by the SUMOylation-specific inhibitor, STE025. (A) The MDCK cells were incubated overnight with the SUMOylation-specific inhibitor, STE025, before infection with IBV for 3 days. The cell survival was determined using a Neutral Red assay. The death of MDCK cells infected with IBV was completely rescued with the STE025, but not PTY-41. (B) The percentages of cell rescue were calculated according to the control group cells with no virus infection.