Table 1.
Design of the two-level three-factor full factorial DOE to study the spray dried FAV-THP cocrystal powder.
| Independent Processing Variables (CPPs) | Levels | |||
|---|---|---|---|---|
| Low (−1) |
Mid-Point (0) | High (+1) |
||
| X1 | Total solute concentration (mg/mL) | 3 | 6 | 9 |
| X2 | Feed pump rate (mL/min) | 1.5 | 3 | 4.5 |
| X3 | Atomizing air flow (L/h) | 357 | 536 | 742 |
|
Responses:
Dependent Variables (CQAs) |
Goal | Acceptable Range | ||
| Y1 | Mass median aerodynamic diameter (MMAD, μm) | 3 | 1–5 | |
| Y2 | Fine particle fraction (FPF, %) | Maximize | ≥30 | |
| Y3 | Emitted fraction (EF, %) | Maximize | ≥60 | |
| Y4 | Crystallinity Index (CI, %) | Maximize | ≥50 | |