Figure 5.

Effect of PTK7 knockdown on tumor growth in xenograft mice. KYSE-30 cells with mock-transfected or PTK7 knockdown (PTK7-KD-6433 and -6434) were subcutaneously xenografted into the dorsal regions of mice. (A) Tumor volumes were recorded for 6 weeks. (B) Images of tumors from mice at 6 weeks after injection (left) and the corresponding weights (right) are shown. Each bar represents the mean ± SD of the three mice. * p < 0.05, ** p < 0.01 vs. mock-transfected cells. (C) Representative images of histologic and immunohistochemical (PTK7 and Ki-67) analysis of tumors are shown in the indicated groups of mice. Scale bar represents 50 μm.