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Pseudoknots from bat coronaviruses. (A) Pseudoknots form when the unpaired bases in an RNA stem loop pair with another single-stranded segment. (B) CoV pseudoknots have a 3-stem architecture, illustrated here for the pseudoknot from SARS-CoV-2. (C) Phylogenetic tree showing five clusters of bat and human CoVs with similar pseudoknot sequences. Representatives from each cluster studied are shown here in cyan for bat CoVs and red for human CoVs.
