Figure 3.

Drugs modulating −1 PRF in SARS-CoV-2 from screening assays. (A) Results from screening a library of 1814 FDA-approved drugs using a dual-luciferase reporter measured in vitro in rabbit-reticulocyte lysate; most of the hits inhibited −1 PRF (dark grey), but some enhanced it (light grey). Error bars represent the standard error of the mean from 3 replicates. (B) Inhibition of −1 PRF by selected compounds in A549 human lung epithelial cells transfected with a bi-fluorescent reporter system. Error bars represent standard error of the mean from 4 replicates.