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. 2022 Feb 17;23(4):2213. doi: 10.3390/ijms23042213

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A–D): Evaluation of viability determined by ATP levels and caspase 3/7 activation of healthy colon (A,B, respectively) and SI (C,D, respectively) organoids when exposed to 0.1, 1, 10, and 30 µM gefitinib for 24 h in black, 48 h in dark grey and 72 h in light grey, compared with Untreated controls. Values are in % of luminescence. For each time point the average of Unt. Ctrl was set to 100%. SD was calculated for each condition. Legend: Ctrl, control; SD, standard deviation; SI, small intestine; Unt, untreated; Veh, vehicle (with 0.1% DMSO). * p-value = 0.01; ** p-value = 0.003; *** p-value = 0.0004; **** p-value = 0.0001.