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. 2022 Feb 5;12(2):149. doi: 10.3390/metabo12020149

Figure 2.

Figure 2

Dysregulated Male LRRK2 PD Metabolic Pathways. (A) Altered metabolites in male LRRK2 PD are enriched for amino acids and metabolites associated with glycolysis and gluconeogenesis. (B) Altered metabolites glucose, alanine, and lactate are central components of the glucose-alanine and Cori cycle important for supporting gluconeogenesis in the liver. Detected differential metabolites are highlighted in orange boxes. Double arrows represent multiple enzymatic transformational steps. Abbreviations: G6P; Glucose-6-phosphate, F6P; Fructose-6-phosphate, F16BP; Fructose 1,6-biphosphate, DHAP; dihydroxyacetone phosphate, GA3P; Glyceraldehyde-3-phosphate, 13BP; 1,3-Biphosphoglycerate, 3PG; 3-Phosphoglycerate, 2PG; 2-Phosphoglycerate, PEP; Phosphoenolpyruvate.