Figure 4.

Diagnostic model performance in the test sample set and indeterminate sample cases. (A,B) Model predictive score plot of 12 test samples based on the mass spectral profile under positive ion mode (A) and negative ion mode (B). (C). Model prediction analysis of indeterminate case TC13. Micro-region with suspicious foci were delineated on an enlarged view of the H&E stain image. Underneath is the MSI image. The integrated result of computational prediction from both positive and negative models is shown on the right. The predicted value is below 0.35: it does not belong to this classification; the predicted value is between 0.35~0.65: it may belong to this classification; the predicted value is above 0.65: it belongs to this classification. Malignancy is the basic output if having both benign and malignant predictions.