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. 2022 Feb 24;14:37. doi: 10.1186/s13195-022-00979-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — A CONSORT diagram of the FINGER exploratory Thioredoxin-80 sub-study. CERAD, Consortium to Establish a Registry for Alzheimer’s Disease. B Serum Trx80 levels by disease diagnosis. Participants were divided into four groups according to their disease state. FINGER cohort participants and SCI, MCI, and AD participants from the GEDOC cohort. The graph shows serum Trx80 levels (ng/ml) between groups. p values are calculated from one-way ANCOVA adjusted for age. C Hippocampal volume of patients with highest and lowest serum Trx80 levels in FINGER cohort. The graph shows hippocampal volume (ml) between groups. t-test was used to analyze the differences between groups. D Serum Trx80 levels in ApoE4 carriers and non-carriers from merged GEDOC and FINGER cohorts. The graph shows serum Trx80 levels (ng/ml) between groups. p values are calculated from one-way ANCOVA adjusted for age. E Western-bot analysis of Trx80 levels in post-mortem AD and non-AD brain samples. Samples are sorted by APOE genotype ApoE3/ApoE3 (E3/E3) and E4/E4. Student t-test was used to analyze the differences between groups. *p < 0.05; **p < 0.01; ****p < 0.0001