Figure 3.

Micro-vascular reactivity and itching assessments. (A,B) Bar charts report the means and peaks of blood perfusions at baseline, after creams application and after histamine (his) and cowhage (cow) induction. (C,D) Bar chart depict peak and area under the curve pain reported by the participants on a scale from 0 to 100. Blue colors represent areas treated with vehicle cream (VC), whereas red colors indicate areas treated with S. ramosissima-based cream (SC). “BS” indicates data obtained at baseline. “24 h” reports data relative to group 1 and “48 h” indicates data relative to group 2. “His” and “Cow” indicates data relative to area treated with histamine or cowhage, respectively. Error bars report standard deviation (SD). **, ***, = RM-ANOVA test significance. # = t-test statistical significance.