Figure 4.

MEK1 protein–ligand interaction plots of native inhibitor (A) and selected flavonoids (B–F). The residues forming non-bonding interactions are shown as red bristles, while residues forming hydrogen bond and the bound ligand are shown as ball-and-stick representations. The carbon atoms are shown as black balls, nitrogen atoms as blue balls, oxygen atoms as red balls, fluorine atoms as green balls, bromine atom as pink balls, and iodine atom as a yellow ball. The interacting residues common with those of the native inhibitor are shown in circles. The hydrogen bonds are shown as green dashed lines labeled with bond length (in Å).