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Proline concentration (A), collagen biosynthesis (B), and prolidase activity (C) in C32WT and C32POX− cells upon treatment with metformin (0–20 mM) for 24 h. The mean values with standard deviation (SD) from 3 experiments performed in duplicates are presented. Asterisks * indicate statistical differences between studied cells compared to controls at p < 0.001.
