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. 2022 Feb 22;7(4):e150041. doi: 10.1172/jci.insight.150041

Figure 6. Hepatic Atf5 overexpression promotes metabolism homeostasis.

Figure 6

(A) GTT and (B) ITT of HFD-fed male mice (12 weeks HFD) infected with Ad-GFP (control) or Ad-Atf5. n = 6. (C) Levels of fasting glucose (16-hour fasting) and serum lipids (4-hour fasting), (D) hepatic TG content, and (E) liver ISR and ISG gene expression in Ad-GFP and Ad-Atf5–infected mice. n = 5–6. (F) GTT of male mice on a HFD supplemented with vehicle or MMF (45 mg/Kg body weight, mixed in the HFD) for 6 weeks. Left panel: 16-hour fasting blood glucose. n = 4–5. Experiments repeated in 2 separate cohorts. Values are presented as mean ± SEM. Significance was determined by 2-way ANOVA for GTT and unpaired, 2-tailed Student’s t test for 2-group comparisons. *P < 0.05; #P < 0.01; $P < 0.001.