Table 3.

The main differences between diseased and healthy specimens of Baikal sponges.

Over-Represented Viral Taxa or Functions	Baikal Water vs. Sponges		Healthy vs. Diseased
	LBw.4 g	B. bacillifera	2478.2 h	2475.1 d
Families	Siphoviridae	Podoviridae, Lavidaviridae, Mimiviridae, Baculoviridae, Bicaudaviridae, Herelleviridae	Siphoviridae, Phycodnaviridae, Mimiviridae, Baculoviridae, Bicaudaviridae, Herelleviridae	Myoviridae
Virotypes	Arthrobacter phage Decurro, Synechococcus phages S-SKS1 and ACG-2014h, Prochlorococcus phage P-GSP1, Xylella phages Sano and Xfas53	Cellulophaga phages, (phi38:1, phi10:1, and phi19:3), Yellowstone lake virophage 6 and others	Nonlabens phage P12024S, Gordonia phages (GMA1, Wizard, etc.), Synechococcus phage S-CBS2	Enterobacteria phage Sf101, Bdellovibrio phage phi1422, Croceibacter phage P2559Y
Putative hosts	Cyanobacteria, Actinobacteria, Firmicutes, Euryarchaeota	Bacteroidetes, Crenarchaeota, Amoebozoa, Arthropoda, Mimiviridae	Chlorophyta, Amoebozoa,	Proteobacteria
Functional categories (except “Metabolism”)	‘Replication and repair’, ‘Environmental adaptation’, ‘Digestive system’	‘Folding, sorting and degradation’, ‘Translation’, ‘Cell growth and death’, ‘Aging’	‘Signal transduction’	‘Cell growth and death’
Metabolic functions	‘Metabolism of terpenoids and polyketides’, ‘Glycan biosynthesis and metabolism’, ‘Carbohydrate metabolism’	‘Nucleotide metabolism’, ‘Xenobiotics biodegradation and metabolism’	Almost all (except ‘Amino acid metabolism’), ‘Folate biosynthesis’	‘Amino acid metabolism’, ‘Riboflavin metabolism’