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. 2022 Feb 22;7(4):e152690. doi: 10.1172/jci.insight.152690

Figure 4. Immune cell landscape and neutrophil recruitment to MRSA are altered 21 days after bleomycin-induced lung fibrosis.

Figure 4

(A) Lung sections from mice treated with saline + MRSA or bleomycin + MRSA and stained with H&E. Scale bars: 100 μm (top row), 25 μm (bottom row). (B) UMAP multidimensional reduction of CD45+ lung cells after saline + MRSA or bleomycin + MRSA treatment. (C) Quantification of lung immune cell types identified via flow cytometry from mice treated with saline + MRSA (n = 5) or bleomycin + MRSA (n = 6). Representative of 2 independent experiments. Data represent the means ± SD. Statistical analysis by unpaired Student’s t test. **P < 0.01, ***P < 0.001, ****P < 0.0001. Mo-AMs, monocyte-derived alveolar macrophages; TR-AMs, tissue-resident alveolar macrophages.