Table 2.
The number of patients with BRCA or HRD status in the included studies.
Author | Study | Year | No. of Patients | No. of Patients with pCR | ||||||
---|---|---|---|---|---|---|---|---|---|---|
mBRCA+ | WtBRCA | HRD+ | HRD- | mBRCA+ | WtBRCA | HRD+ | HRD- | |||
Fasching et al. [22] | GeparPLA | 2020 | 20 | 16 | 27 | 12 | 6 | 16 | ||
Mayer et al. [23] | TBCRC030 | 2020 | 6 | 69 | 39 | 17 | 1 | 5 | 5 | 1 |
Yuan et al. [24] | NCT01525966 | 2020 | 11 | 44 | 8 | 20 | ||||
Sharma et al. [25] | NeoSTOP | 2020 | 17 | 65 | 13 | 32 | ||||
Fontaine et al. [26] | BSMO | 2019 | 9 | 42 | 7 | 22 | ||||
Hahnen et al. [28], Loibl.S et al. [27] | GeparSixto | 2017, 2018 |
26 | 120 | 74 | 27 | 17 | 66 | 48 | 11 |
Loibl et al. [29], Telli et al. [30] | BrighTNess | 2018 | 70 | 406 | 225 | 104 | 38 | 222 | 138 | 42 |
Sella et al. [35] | 2018 | 14 | 23 | 9 | 10 | |||||
Sharma et al. [31] | PROGECT | 2017 | 27 | 133 | 16 | 75 | ||||
Connolly et al. [32] | TBCRC 008 | 2016 | 12 | 6 | 8 | 1 | ||||
Telli et al. [33] | PrECOG 0105 | 2015 | 17 | 73 | 50 | 15 | 9 | 22 | 33 | 3 |
Kaklamani et al. [34] | NCT01372579 | 2015 | 3 | 27 | 12 | 14 | 2 | 11 | 9 | 2 |
Silver et al. [36] | 2010 | 2 | 26 | 2 | 4 |
Abbreviations: HRD: homologous recombination deficiency; pCR: pathological complete response CR: complete response; mBRCA: mutated BRCA; WtBRCA: wildtype BRCA.