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. 2022 Feb 12;23(4):2046. doi: 10.3390/ijms23042046

Figure 5.

Figure 5

Moderately reduced platelet aggregation by bi-ORbIT at high-shear flow. Whole-blood was preincubated for 10 min in parallel with bi-ORbIT (20 µg/mL), CLB-RAg35 mAb (RAg35, 10 µg/mL), or saline (control). Experimental setup and analysis as shown in Figure 3. (A) Representative end-stage brightfield microscopy images per microspot in the absence or presence of bi-ORbIT. Bar = 10 µm. (B) Cumulative plots of scaled data per parameter (0–10), showing the effects of bi-ORbIT. (C) Heatmap representation of control-subtracted data for bi-ORbIT and RAg35. Color coding indicates decrease (green) or increase (red) in comparison to control runs (n = five donors, paired Student’s t-test, p < 0.05). For raw data, see Table S2.