| PDB | Protein Data Bank |
| nAbs | neutralizing antibodies |
| RBD | receptor binding domain |
| NTD | N-terminal domain |
| ACE2 | angiotensin-converting enzyme 2 |
| RSA | relative solvent accessibility |
| ΔΔGb | change in binding affinity upon mutation |
| RMSD | root mean square deviation |
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