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. 2022 Feb 17;23(4):2230. doi: 10.3390/ijms23042230

Figure 3.

Figure 3

RNAseq analysis in naïve T cells and during Treg polarization conditions. (a–c) Gene set enrichment analysis (GSEA) of CD4+ naïve T cells (Tn) from WT and Aim2−/− and from WT and Aim2−/− T cells stimulated under Treg polarizing conditions (Treg) for 2 days (n = 4/group). GO = gene ontology database; CC = cellular component; BP = biological process; NES = normalized enrichment score; RA = reactome database. (d) Heatmap showing the expression of Treg-associated genes in Tn and Treg from WT and Aim2−/− mice (n = 4/group). Color coded values represent log2 values of the normalized counts, mean-centered for each gene. (e) GSEA analysis of Treg-associated genes in Tn (left) and Treg (right) cells from WT and Aim2−/− mice (n = 4/group).