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. 2022 Feb 17;23(4):2226. doi: 10.3390/ijms23042226

Figure 6.

Figure 6

Effects of halogenated α-PVP derivatives on CPP test in CD-1 mice. Bars represent mean ± SEM of the preference score (difference between the time spent in the drug-paired compartment on the test day and the pre-conditioning day). Panel (A) saline, 3-F-α-PVP 10 mg kg−1, and 3-F-α-PVP 25 mg kg−1, N = 14/group and 3-F-α-PVP 2.5 mg kg−1, N = 13/group. Panel (B) saline and 4-F-α-PVP 2.5 mg kg−1, N = 14/group; 4-F-α-PVP 10 mg kg−1 and 4-F-α-PVP 25 mg kg−1, N = 13/group. Panel (C) saline and 3-Cl-α-PVP, N = 14. Panel (D) saline, N = 13/group; 4-Cl-α-PVP 2.5 mg kg−1, N = 12/group, 4-Cl-α-PVP 10 mg kg−1, and 4-Cl-α-PVP 25 mg kg−1, N = 14/group. Panel (E) saline, 3,4-Cl2-α-PVP 2.5 mg kg−1, and 3,4-Cl2-α-PVP 25 mg kg−1, N = 14/group and 3,4-Cl2-α-PVP 10 mg kg−1, N = 13/group. Panel (F) saline and 3-Br-α-PVP 25 mg kg−1, N = 14, 3-Br-α-PVP 2.5 mg kg−1 and 3-Br-α-PVP 10 mg kg−1, N = 12/group. Panel (G) saline, N = 12/group, 4-Br-α-PVP 2.5 mg kg−1 and 4-Br-α-PVP 10 mg kg−1, N = 14/group and 4-Br-α-PVP 25 mg kg−1, N = 13/group. * p < 0.05, ** p < 0.01 and *** p < 0.001 vs. saline.