Table 3. Overall survival based on the antioxidant gene signature and clinical data for sarcoma.
| Univariate Cox analysis | Multivariate Cox analysis | ||||||
| HR | 95%CI | P | HR | 95%CI | P | ||
| Age | 1.020 | 1.005–1.036 | 0.010 | 1.040 | 1.017–1.062 | 0.000 | |
| Sex (Female) | 0.853 | 0.571–1.275 | 0.439 | ||||
| Ethnicity (Asian) | |||||||
| Black | 1.085 | 0.132–8.924 | 0.939 | ||||
| White | 0.791 | 0.108–5.771 | 0.817 | ||||
| Histological type (DLP) | |||||||
| LMS | 0.844 | .513–1.389 | 0.505 | ||||
| MFS | 0.703 | .328–1.507 | 0.365 | ||||
| Other | 0.739 | .319–1.710 | 0.480 | ||||
| UPS | 0.901 | .481–1.691 | 0.746 | ||||
| Tumor site (Extremity) | 0.813 | 0.524–1.260 | 0.354 | ||||
| Metastasis (No) | 3.009 | 1.831–4.946 | 0.000 | 3.702 | 2.089–6.562 | 0.000 | |
| Margin status (R0) | 2.553 | 1.668–3.909 | 0.000 | 2.356 | 1.351–4.111 | 0.003 | |
| Multifocal indicator (No) | 2.400 | 1.500–3.841 | 0.000 | 1.256 | 0.601–2.627 | 0.544 | |
| Radiotherapy (No) | 0.992 | 0.621–1.585 | 0.973 | ||||
| Pharmacotherapy (No) | 1.380 | 0.814–2.339 | 0.231 | ||||
| Risk score | 1.552 | 1.331–1.808 | 0.000 | 1.450 | 1.184–1.776 | 0.000 | |
HR, hazard ratio; CI, confidence interval; DLP, dedifferentiated liposarcoma; LMS, leiomyosarcoma; MFS, myxofibrosarcoma; UPS, undifferentiated pleomorphic sarcoma.