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. 2022 Feb 10;14(3):1407–1428. doi: 10.18632/aging.203885

Table 3. Overall survival based on the antioxidant gene signature and clinical data for sarcoma.

Univariate Cox analysis Multivariate Cox analysis
HR 95%CI P HR 95%CI P
Age 1.020 1.005–1.036 0.010 1.040 1.017–1.062 0.000
Sex (Female) 0.853 0.571–1.275 0.439
Ethnicity (Asian)
Black 1.085 0.132–8.924 0.939
White 0.791 0.108–5.771 0.817
Histological type (DLP)
LMS 0.844 .513–1.389 0.505
MFS 0.703 .328–1.507 0.365
Other 0.739 .319–1.710 0.480
UPS 0.901 .481–1.691 0.746
Tumor site (Extremity) 0.813 0.524–1.260 0.354
Metastasis (No) 3.009 1.831–4.946 0.000 3.702 2.089–6.562 0.000
Margin status (R0) 2.553 1.668–3.909 0.000 2.356 1.351–4.111 0.003
Multifocal indicator (No) 2.400 1.500–3.841 0.000 1.256 0.601–2.627 0.544
Radiotherapy (No) 0.992 0.621–1.585 0.973
Pharmacotherapy (No) 1.380 0.814–2.339 0.231
Risk score 1.552 1.331–1.808 0.000 1.450 1.184–1.776 0.000

HR, hazard ratio; CI, confidence interval; DLP, dedifferentiated liposarcoma; LMS, leiomyosarcoma; MFS, myxofibrosarcoma; UPS, undifferentiated pleomorphic sarcoma.