Table 3.
Adjusted estimates of main effects of ApoE e4 status and education group
| Whole sample | Restricted sample (sensitivity analysis) | ||||||
|---|---|---|---|---|---|---|---|
| Cognitive measure | B | 95% CI | p | B | 95% CI | p | |
| CVLT verbal learning | ApoE e4 | −.028 | [−.164; .108] | .687 | −.040 | [−.202; .122] | .627 |
| Education | −.169 | [−.307; −.032] | .016* | −.067 | [−.236; .102] | .435 | |
| CVLT memory retention | ApoE e4 | −.189 | [−.324; −.054] | .006* | −.125 | [−.254; .004] | .057 |
| Education | −.305 | [−.442; −.169] | < .001* | −.100 | [−.237; .036] | .150 | |
| Logical Memory Delay | ApoE e4 | −.099 | [−.235; .037] | .153 | −.064 | [−.233; .106] | .461 |
| Education | −.503 | [−.655; −.352] | < .001* | −.449 | [−.628; −.269] | < .001* | |
| Logical Memory retention | ApoE e4 | −.026 | [−.183; .131] | .745 | .011 | [−.176; .198] | .907 |
| Education | −.074 | [−.220; .073] | .325 | −.078 | [−.251; .095] | .379 | |
| Digit Span Backward | ApoE e4 | −.037 | [−.184; .110] | .619 | −.019 | [−.203; .165] | .837 |
| Education | −.400 | [−.538; −.261] | < .001* | −.361 | [−.543; −.179] | < .001* | |
| ROCF Delay | ApoE e4 | −.037 | [−.211; .137] | .672 | .005 | [−.208; .217] | .965 |
| Education | −.419 | [−.587; −.251] | < .001* | −.346 | [−.545; −.147] | .001* | |
| ROCF retention | ApoE e4 | .123 | [−.044; .291] | .147 | .135 | [−.078; .349] | .212 |
| Education | −.041 | [−.227; .146] | .663 | −.066 | [−.285; .153] | .552 | |
| Semantic fluency | ApoE e4 | −.121 | [−.251; .009] | .067 | −.020 | [−.169; .129] | .791 |
| Education | −.277 | [−.409; −.146] | < .001* | −.216 | [−.371; −.062] | .006* | |
| BNT | ApoE e4 | −.056 | [−.194; .082] | .429 | −.078 | [−.225; .068] | .292 |
| Education | −.454 | [−.587; −.321] | < .001* | −.399 | [−.548; −.250] | < .001* | |
| Trails | ApoE e4 | .048 | [−.088; .185] | .488 | .043 | [−.105; .191] | .569 |
| Education | .274 | [.135; .412] | < .001* | .352 | [.198; .507] | < .001* | |
| Letter fluency | ApoE e4 | −.025 | [−.166; .117] | .731 | .042 | [−.124; .208] | .621 |
| Education | −.487 | [−.625; −.348] | < .001* | −.346 | [−.514; −.177] | < .001* | |
| Digit Symbol Test | ApoE e4 | .005 | [−.118; .128] | .934 | .051 | [−.095; .197] | .491 |
| Education | −.578 | [−.705; −.450] | < .001* | −.441 | [−.598; −.284] | < .001* | |
Note. Reference category ApoE e4 status = non-carriers; B = unstandardized coefficient; CI = confidence interval;
*
FDR-corrected significant; adjusted for age, sex/gender, and testing site;
CVLT = California Verbal Learning Test; ROCF = Rey-Osterrieth Complex Figure; BNT = Boston Naming Test; WRAT-3 = Wide Range Achievement Test 3; ; all cognitive scores were standardized; restricted sample excluded participants with cognitive impairment.