Table 5.
Effect estimates of ApoE e4 status, education group, and their interaction on cognitive measures across strata of sex/gender and age groups
| Sex/Gender | Age Group | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Men | Women | Up to 68 years | Older than 68 years | ||||||||||
| Cognitive measure | B | 95% CI | p | B | 95% CI | p | B | 95% CI | p | B | 95% CI | p | |
| CVLT verbal learning | ApoE e4 | −.156 | [−.466; .153] | .322 | .000 | [−.153; .154] | .999 | −.081 | [−.272; .109] | .402 | −.007 | [−.205; .191] | .947 |
| Education | −.144 | [−.447; .159] | .350 | −.167 | [−.324..011] | .036* | −.027 | [−.221; .167] | .786 | −.313 | [−.510; −.116] | .002* | |
| ApoE e4*Education | −.336 | [−.947; .275] | .281 | .157 | [−.162; .475] | .335 | .020 | [−.380; .420] | .923 | .056 | [−.346; .458] | .784 | |
| CVLT memory retention | ApoE e4 | −.252 | [−.612; .108] | .171 | −.192 | [−.337; −.048] | .009* | −.074 | [−.249; .101] | .408 | −.312 | [−.522; −.101] | .004* |
| Education | −.104 | [−.459; .251] | .566 | −.351 | [−.496; −.205] | < .001* | −.322 | [−.503; −.142] | < .001* | −.323 | [−.531; −.114] | .002* | |
| ApoE e4*Education | −.005 | [−.721; .712] | .990 | −.481 | [−.778; −.184] | .001* | −.347 | [−.707; .013] | .059 | −.385 | [−.810; .039] | .075 | |
| Logical Memory | ApoE e4 | −.216 | [−.519; .087] | .163 | −.084 | [−.235; .067] | .273 | −.026 | [−.220; .168] | .791 | −.182 | [.376; .012] | .067 |
| Education | −.245 | [−.551; .060] | .115 | −.565 | [−.742; −.389] | < .001* | −.463 | [−.657; −.269] | < .001* | −.571 | [−.809; −.333] | < .001* | |
| ApoE e4*Education | .328 | [−.274; .931] | .285 | .064 | [−.260; .389] | .697 | .251 | [−.168; .670] | .239 | −.002 | [−.417; .412] | .992 | |
| Logical Memory retention | ApoE e4 | .008 | [−.358; .374] | .996 | −.037 | [−.206; .132] | .666 | .135 | [−.072; .343] | .201 | −.200 | [−.419; .020] | .074 |
| Education | −.013 | [−.395; .369] | .947 | −.094 | [−.264; .077] | .280 | −.088 | [−.292; .117] | .401 | −.093 | [−.322; .137] | .426 | |
| ApoE e4*Education | −.209 | [−.956; .538] | .582 | −.035 | [−.383; .312] | .841 | .113 | [−.316; .541] | .606 | −.219 | [−.694; .256] | .363 | |
| Digit Span Backward | ApoE e4 | −.330 | [−.637; −.023] | .035* | .028 | [−.143; .199] | .748 | −.101 | [−.304; .103] | .332 | .012 | [−.188; .213] | .906 |
| Education | −.192 | [−.506..123] | .232 | −.442 | [−.692; −.282] | < .001* | −.288 | [−.494; −.081] | .006* | −.520 | [−.725; −.315] | < .001* | |
| ApoE e4*Education | −.195 | [−.833; .443] | .549 | −.346 | [−.671; −.020] | .037* | −.431 | [−.843; −.019] | .040 | −.231 | [−.650; .188] | .280 | |
| ROCF delay | ApoE e4 | .150 | [−.229; .528] | .434 | −.081 | [−.266; .104] | .383 | .062 | [−.190; .314] | .622 | −.150 | [−.365; .065] | .171 |
| Education | −.447 | [−.869; −.025] | .038* | −.420 | [−.609; −.232] | < .001* | −.431 | [−.661; −.202] | < .001* | −.430 | [−.653; −.207] | < .001* | |
| ApoE e4*Education | −.031 | [−.764; .702] | .933 | −.124 | [−.496; .248] | .509 | −.228 | [−.675; .219] | .314 | −.067 | [−.374; .508] | .764 | |
| ROCF retention | ApoE e4 | .093 | [−.353; .538] | .674 | .130 | [−.051; .310] | .159 | .162 | [−.080; .403] | .189 | .093 | [−.128; .313] | .403 |
| Education | .007 | [−.399; .413] | .973 | −.053 | [−.239; .134] | .578 | −.100 | [−.347; .146] | .424 | .013 | [−.261; .287] | .923 | |
| ApoE e4*Education | .039 | [−.904; .981] | .933 | −.178 | [−.532; .176] | .324 | −.253 | [−.791; .284] | .353 | .003 | [−.394; .399] | .989 | |
| Semantic fluency | ApoE e4 | −.408 | [−.750; −.065] | .020* | −.050 | [−.190; .089] | .481 | −.168 | [−.362; .027] | .091 | −.077 | [−.256; .102] | .400 |
| Education | −.188 | [−.525; .148] | .273 | −.289 | [−.431; −.148] | < .001* | −.236 | [−.434; −.037] | .020* | −.335 | [−.514; −.157] | < .001* | |
| ApoE e4*Education | −.059 | [−.741; .624] | .866 | .181 | [−.108; .471] | .220 | .019 | [−.384; .422] | .927 | .166 | [−.200; .531] | .374 | |
| BNT | ApoE e4 | −.002 | [−.307; .303] | .990 | −.081 | [−.237; .075] | .308 | −.055 | [−.226; .116] | .528 | −.071 | [−.290; .147] | .522 |
| Education | −.269 | [−.568; .030] | .078 | −.503 | [−.651; −.355] | < .001* | −.411 | [−.582; −.240] | < .001* | −.516 | [−.735; −.297] | < .001* | |
| ApoE e4*Education | .100 | [−.495; .696] | .741 | −.063 | [−.380; .254] | .697 | −.143 | [−.489; .202] | .416 | .122 | [−.340; .583] | .604 | |
| Trails | ApoE e4 | .108 | [−.215; .432] | .512 | .038 | [−.113; .189] | .623 | .041 | [−.142; .224] | .663 | .049 | [−.157; .255] | .642 |
| Education | .188 | [−.130; .505] | .246 | .294 | [.139; .448] | < .001* | .311 | [.123; .499] | .001* | .247 | [.041; .452] | .019* | |
| ApoE e4*Education | .470 | [−.169; 1.108] | .149 | .195 | [−.120; .511] | .225 | .323 | [−.057; .703] | .096 | .182 | [−.238; .601] | .396 | |
| Letter fluency | ApoE e4 | −.071 | [−.393; .251] | .667 | −.024 | [−.179; .132] | .767 | −.137 | [−.335; .062] | .176 | .073 | [−.130; .276] | .480 |
| Education | −.279 | [−.601; .042] | .089 | −.541 | [−.697; −.384] | < .001* | −.386 | [−.586; −.185] | < .001* | −.577 | [−.774; .380] | < .001* | |
| ApoE e4*Education | −.322 | [−.948; .305] | .315 | −.050 | [−.369; .269] | .759 | −.316 | [−.719; .087] | .124 | .085 | [−.323; .493] | .682 | |
| Digit Symbol Test | ApoE e4 | .052 | [−.239; .342] | .727 | −.016 | [−.152; .121] | .822 | .020 | [−.162; .202] | .830 | −.018 | [−.204; .167] | .847 |
| Education | −.511 | [−.808; −.215] | .001* | −.594 | [−.737; −.450] | < .001* | −.532 | [−.716; −.347] | < .001* | −.651 | [−.828; −.474] | < .001* | |
| ApoE e4*Education | −.313 | [−.865; .239] | .267 | .113 | [−.179; .406] | .447 | −.191 | [−.576; .193] | .329 | .225 | [−.130; .580] | .213 | |
Note. Reference category ApoE e4 status = non-carriers; B = unstandardized coefficient; CI = confidence interval;
*
FDR-corrected significant; adjusted for age, sex/gender, and testing site;
CVLT = California Verbal Learning Test; ROCF = Rey-Osterrieth Complex Figure; BNT = Boston Naming Test; WRAT-3 = Wide Range Achievement Test 3; all cognitive scores were standardized.