Table 3.

Multivariate analyses for overall, cancer-specific, and disease-free survivals in advanced UTUC patients.

	Overall Survival			Cancer-Specific Survival			Disease-Free Survival
Variables	HR	95% CI	p-Value	HR	95% CI	p-Value	HR	95% CI	p-Value
Adjuvant chemotherapy
No	1			1			1
Yes	0.599	0.419–0.857	0.005 *	0.598	0.391–0.914	0.018 *	0.456	0.310–0.673	<0.001 *
Age
<70	1			1			1
≥70	1.727	1.272–2.346	<0.001 *	1.321	0.917–1.902	0.134	1.176	0.856–1.616	0.317
Tumor size
<3 cm	1			1			1
≥3 cm	1.188	0.859–1.643	0.299	1.473	0.974–2.226	0.066	1.377	0.978–1.939	0.067
Tumor grade
Low grade	1			1			1
High grade	2.526	1.033–6.181	0.042 *	8.184	1.139–58.824	0.037 *	3.772	1.197–11.885	0.023 *
Multifocality
No	1			1			1
Yes	1.274	0.951–1.707	0.104	1.375	0.966–1.957	0.077	1.415	1.043–1.920	0.026 *
Lymphovascular invasion
No	1			1			1
Yes	1.258	0.935–1.693	0.129	1.395	0.970–2.006	0.073	1.193	0.870–1.635	0.274
Pathological T stage
pT3	1			1			1
pT4	2.390	1.588–3.596	<0.001 *	2.234	1.377–3.627	0.001 *	1.654	1.033–2.650	0.036 *
Pathological N stage
pN0 + pNx	1			1			1
pN1 + pN2	2.234	1.397–3.572	0.001 *	2.323	1.361–3.963	0.002 *	2.888	1.755–4.752	<0.001 *

* p < 0.05. HR—hazard ratio; CI—confidence interval.