Figure 1.

S100B-centered protein–protein interaction (PPI) network generated by STRING using high confidence level of 0.7 [47]. In this network, the nodes correspond to proteins, whereas the edges show predicted or known functional associations. Seven types of evidence are used to build the corresponding network, and are indicated by the differently colored lines: a green line represents neighborhood evidence; a red line—the presence of fusion evidence; a purple line—experimental evidence; a blue line—co-occurrence evidence; a light blue line—database evidence; a yellow line—text mining evidence; and a black line—co-expression evidence [47]. This network includes 53 proteins connected by 205 interactions. As a result, an average node degree of this network is 7.74.