Table 3.

Culture conditions and yields of bioactive secondary metabolites produced by endophytic fungi.

No.	Endophytic Fungus	Host Plant	Culture Conditions	Secondary Metabolites	Yield	Ref.
1	Hansfordia biophila	Hedychium acuminatum Roscoe	Inoculated in potato glucose broth (PDB) medium and shaken at 120 rpm at 25 °C for 7 days.	Tannin	41.6 μm·mL−1	[121]
2	Aspergillus terreus	Ficus elastica	Inoculated into PDB medium and incubated at 30 °C for 20 days on a rotatory shaker incubator at 140 rpm.	Camptothecin	320 μg/L	[122]
3	Guignardia mangiferae HAA11	Taxus x media	Inoculated into (PDB) medium and incubated at 200 rpm at 28 °C for 5 days.	Paclitaxel	720 ng/L	[123]
4	Papulasora sp.S6	Phellodendron amurense Rupr	Mutagenesis by UV, X-ray rays, and NaNO2, inoculated in PDB medium, and shaken at 100 rpm at 28 °C for 7 days.	Berberine	12.28 mg/L	[124]
5	Actinoplanes teichomyceticus		Improvement of the output of teicoplanin by genome shuffling; Inoculated teicoplanin medium and cultured at 28 °C for 15–20 days.	Teicoplanin	3016 μm·mL−1	[125]
6	Phialocephala fortinii	Podophyllum peltatum	Inoculated in Sabouraud’s dextrose agar (SDA) and cultured at 23 °C for 4–6 weeks.	Podophyllotoxin	189 µg/L	[126]
7	Entrophospora infrequens RJMEF001	Nothapodytes foetida	Inoculated into wheat bran containing Sabouraud’s broth, and incubation was carried out at 28 ± 2 °C for 28 days.	Camptothecin	503 ± 25 μg/100 g dry cell mass (in Sabouraud broth)	[127]
8	Epicoccum nigrum SZMC 23769	Hypericum perforatum	Fungal isolates were grown in potato dextrose broth (PDB) for 7 days at 25 °C.	Hypericin, Emodin	117.1 μg/mL, 87.7 μg/mL	[128]