Table 2.
Virucidal effects of CAC-717 on various DNA viruses. Viral titer is shown as log10 TCID50/25 μL (mean ± SE). Values are representative values from two separate experiments.
| Viruses | Solution | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| CAC-717 | CAC-717 + HEPES 1 | Tap Water | Maintenance Medium | ||||||
| 2 s | 10 s | 30 s | 1 min | 15 min | 30 min & 60 min | 60 min | 60 min | 60 min | |
| Enveloped | |||||||||
| Herpesviridae | |||||||||
| IBRV | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | 6.71 ± 0.13 | 6.71 ± 0.13 | 6.96 ± 0.13 |
| PrV | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | 4.83 ± 0.25 | 4.83 ± 0.00 | 4.96 ± 0.13 |
| CHV-1 | ≤0.58 ** | ≤0.58 ** | ≤0.58 ** | ≤0.58 ** | ≤0.58 ** | ≤0.58 ** | 3.33 ± 0.25 | 2.96 ± 0.13 | 3.71 ± 0.13 |
| EHV-1 | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | 4.83 ± 0.25 | 4.96 ± 0.13 | 4.96 ± 0.13 |
| Non-enveloped | |||||||||
| Adenoviridae | |||||||||
| BAdV-7 | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | ≤0.58 * | 6.46 ± 0.13 | 6.33 ± 0.25 | 6.21 ± 0.13 |
| Parvoviridae | |||||||||
| CPV-2 | 2.96 ± 0.13 | ≤0.58 ** | ≤0.58 ** | ≤0.58 ** | ≤0.58 ** | ≤0.58 ** | 3.71 ± 0.13 | 3.46 ± 0.13 | 3.58 ± 0.00 |
1 Nine volumes of CAC-717 were pretreated with one volume of 1.0 M HEPES buffer (pH 7.2). * A reduction in viral titer of ≥4 log10 relative to treatment with maintenance medium; ** A reduction in viral titer of ≥3 log10 relative to treatment with maintenance medium.