Table 3.
Metabolic pathway and function analysis of metabolites associated with formula feeding related to milk sensitization.
| Pathway | Metabolites | Pathway Name | Total | Hits | Raw p | FDR | Function |
|---|---|---|---|---|---|---|---|
| Non-IgE related | 2-Oxoglutaric acid | D-glutamine and D-glutamate metabolism | 6 | 1 | 0.015 | 0.85 | Amino acid metabolism |
| Arginine biosynthesis | 14 | 1 | 0.036 | 0.85 | Amino acid metabolism | ||
| Butanoate metabolism | 15 | 1 | 0.038 | 0.85 | Carbohydrate metabolism | ||
| Pantothenate | Pantothenate and CoA biosynthesis | 19 | 1 | 0.048 | 0.85 | Metabolism of cofactors and vitamins | |
| IgE-related | Lysine | Biotin metabolism | 10 | 1 | 0.019 | 1.00 | Metabolism of cofactors and vitamins |
| Lysine degradation | 25 | 1 | 0.048 | 1.00 | Amino acid metabolism |
Total is the total number of compounds in the pathway; the Hits is the actually matched number from the user uploaded data; the Raw p is the original p value calculated from the enrichment analysis; the FDR is the portion of false positives above the user-specified score threshold. FDR, false discovery rate.