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. 2022 Feb 11;23(4):1988. doi: 10.3390/ijms23041988

Figure 7.

Figure 7

Immunohistochemical detection of annexin-V (Anx-V) in aortic valve leaflets implanted into rat subcutis for 2 days (2d; line above) vs. 14 days (14d; line below). (A) Histological section showing immunopositivity for sporadic valvular cells. (B) Thin section subjected to immunogold labelling showing mitochondrial membranes decorated by gold particles in a valvular cell at early degeneration stage. (C) Histological section showing increased numbers of immunopositive valvular cells, with marked reactivity at their edges (counterposed arrows). (D) Thin section subjected to immunogold labelling showing a membrane-derived pericellular layer decorated by gold particles in a valvular cell at late degeneration stage. Bar: 0.25 mm (A,C); 0.25 μm (B,D).