Table 2.
Influence of doxorubicin and AgNMS complex on cell growth of squamous carcinoma and melanoma cell lines.
| Cell Line | TGI (µM ± SD) | |
|---|---|---|
| Doxo | AgNMS | |
| SCC15 | 1.8 ± 0.6 | 67.3 ± 55.1 |
| SCC4 | 3.5 ± 1.2 | >400 |
| FaDu | 5.4 ± 2.3 | 107.2 ± 64.2 |
| UACC-62 | <0.046 | 2.8 ± 1.1 |
Results expressed as concentration followed by standard deviation (SD) required to elicit total growth inhibition (TGI), calculated by sigmoidal regression using Origin 8.0 software (one experiment in triplicate). Samples: Doxo = doxorubicin (positive control, concentration range: 0.025–25 µg mL−1); AgNMS = silver nimesulide complex (concentration range: 0.25–250 µg mL−1). Human tumor cell lines: SCC15 (squamous cell carcinoma of the tongue); SCC4 (squamous cell carcinoma of the tongue); FaDu (squamous cell carcinoma of the pharynx); UACC-62 (melanoma).