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Signal transduction of pro-and anti-apoptotic Bcl-2 family proteins. Bcl-2 family proteins can accurately promote the mitochondrial permeability transition that allows the outflow of mitochondrial content. They can also induce the opening of mitochondrial MPTP and promote the release of apoptosis-related proteins. The Bcl-2/Bax ratio of the Bcl-2 family determines cell survival or apoptosis after certain stimuli.
