Figure 5.

The four hits inhibit authentic SARS-CoV-2 infection. IFA analysis and images of angeloylgomisin O (A,B), schisandrin B (C,D), procyanidin (E,F), and oleanonic acid (G,H) inhibition of SARS-CoV-2 infection in Caco-2 cells. Caco-2 cells were seeded in 96-well plates. After overnight incubation, cell monolayers were treated with hits; 1 h later, the cells were infected with SARS-CoV-2 at an MOI of 0.5, followed by incubation for 24 h. IFA images showing the viral NP (green) and cell nuclei (blue) are displayed for Caco-2 cells. Cells were treated with different concentrations of angeloylgomisin O (B), schisandrin B (D), procyanidin (F), and oleanonic acid (H). (I) CC₅₀, IC₅₀, and SI values of four hits. Data were presented as the means ± SD from three independent experiments.